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KMID : 1142020190540030189
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Blood Research
2019 Volume.54 No. 3 p.189 ~ p.197
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Favorable long-term survival using consolidation chemotherapy without allogeneic hematopoietic cell transplantation for acute myeloid leukemia with wild-type NPM1 without FLT3-ITD
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Baek Dong-Won
Lee Jung-Min
Kim Ju-Hyung
Cho Hee-Jeong
Ham Ji-Yeon
Suh Jang-Soo
Sohn Sang-Kyun
Moon Joon-Ho
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Abstract
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Background: The role of allogeneic hematopoietic cell transplantation (allo-HCT) compared with consolidation chemotherapy alone in intermediate-risk acute myeloid leukemia (AML) patients with wild-type nucleophosmin/negative or a low level of Fms related tyrosine kinase 3 internal tandem duplication (NPM1wt/FLT3-ITDneg/low) has not yet been elucidated.
Methods: In this study, we retrospectively investigated 88 patients newly diagnosed with AML who received intensive induction chemotherapy at Kyungpook National University Hospital from March 2015 to July 2017. The selection criteria included the presence of results on genetic abnormalities including NPM1 and FLT3-ITD.
Results: According to the European LeukemiaNet (ELN) risk classification, 25 patients (28%) were categorized as favorable, 44 (50%) as intermediate, and 19 (22%) as adverse risk. Among the intermediate-risk patients, 40 were identified as NPM1wt/FLT3-ITDneg/low. Among the patients with NPM1wt/FLT3-ITDneg/low, complete remission (CR) was achieved in 26 patients out of 40 (65%). One-year overall survival (OS) rate was 100% in the favorable-risk group and 87.9% in the NPM1wt/FLT3-ITDneg/low group (P=0.233). Among the intermediate-risk NPM1wt/FLT3-ITDneg/low patients, there was no survival benefit with allo-HCT (N=19) compared to consolidation chemotherapy (N=21; P=0.372). In the multivariate analysis, the ELN risk group [hazard ratio (HR), 6.36; P=0.019] and the achievement of CR (HR, 2.95; P=0.017) were both identified as factors affecting OS of patients with newly diagnosed AML.
Conclusion: Among the AML patients, intermediate-risk NPM1wt/FLT3-ITDneg/low patients and favorable-risk patients showed similar OS rates. Our results suggested that allo-HCT might have limited clinical benefit for the intermediate-risk NPM1wt/FLT3-ITDneg/low patients. Well controlled studies are needed to confirm the current results.
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KEYWORD
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Acute myeloid leukemia, Allogeneic hematopoietic cell transplantation, NPM1, FLT3-ITD
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